When all C–C breaks LO–Ose

Organic peroxides are becoming popular intermediates for novel chemical transformations. The weak O–O bond is readily reduced by transition metals, including iron and copper, to initiate a radical cascade process that breaks C–C bonds. Great potential exists the rapid generation of complexity, originating from ability couple resulting free radicals with wide range partners. First, this review article discusses history synthesis organic peroxides, providing context necessary understand methodology. Then, it highlights 91 examples recent applications functionalization bonds accessed through metal-mediated reduction peroxides. Finally, we provide some comments about safety when working